Wilhelm Foundation’s goal is for all people with Undiagnosed Diseases to be diagnosed

350 million People Living With an Undiagnosed Disease (PLWUD) worldwide.

Genome sequencing can provide answers for 40% of children and adults with undiagnosed diseases, but around 60% still don’t receive a diagnosis.

We have to do more!

Undiagnosed Hackathon is a global, collaborative initiative led by Wilhelm Foundation to shorten the diagnostic odyssey for People Living with Undiagnosed Diseases (PLWUDs).
By bringing together clinicians, researchers, geneticists, data scientists, and lived experience, the Undiagnosed Hackathon tackles the most complex undiagnosed diseases - turning collective intelligence into real diagnoses, follow-up pathways, and scalable solutions.

On 20 October 2026, Wilhelm Foundation hosts the six-hour workshop “Using AI-Enhanced, Multiomic Tools to Solve Rare and Undiagnosed Diseases” at ASHG 2026 in Montréal, where collaborators from beginner to expert diagnostician work hands-on with 10 PLWUD cases still without an answer.

Undiagnosed Hackathon 2026

Singapore (17–20 September 2026) – strengthening precision diagnostics and translational impact in Asia.

Hyderabad, India (3–5 February 2026) – advancing access and capacity in low- and middle-income settings through international collaboration.